The theory transformed theoretical physics and astronomy during the 20th century, superseding a 200-year-old theory of mechanics created primarily by Isaac Newton. It introduced concepts including 4-dimensional spacetime as a unified entity of space and time, relativity of simultaneity, kinematic and gravitational time dilation, and length contraction. In the field of physics, relativity improved the science of elementary particles and their fundamental interactions, along with ushering in the nuclear age.

In theoretical physics, quantum field theory (QFT) is a theoretical framework that combines classical field theory, special relativity, and quantum mechanics. QFT is used in particle physics to construct physical models of subatomic particles and in condensed matter physics to construct models of quasiparticles.

QFT treats particles as excited states (also called quanta) of their underlying quantum fields, which are more fundamental than the particles.

The Standard Model of particle physics is the theory describing three of the four known fundamental forces (electromagnetic, weak and strong interactions — excluding gravity) in the universe and classifying all known elementary particles. It was developed in stages throughout the latter half of the 20th century, through the work of many scientists worldwide, with the current formulation being finalized in the mid-1970s upon experimental confirmation of the existence of quarks. Since then, proof of the top quark (1995), the tau neutrino (2000), and the Higgs boson (2012) have added further credence to the Standard Model. In addition, the Standard Model has predicted various properties of weak neutral currents and the W and Z bosons with great accuracy.

In quantum mechanics, the uncertainty principle (also known as Heisenberg's uncertainty principle) is any of a variety of mathematical inequalities asserting a fundamental limit to the accuracy with which the values for certain pairs of physical quantities of a particle, such as position, x, and momentum, p, can be predicted from initial conditions.

Such variable pairs are known as complementary variables or canonically conjugate variables; and, depending on interpretation, the uncertainty principle limits to what extent such conjugate properties maintain their approximate meaning, as the mathematical framework of quantum physics does not support the notion of simultaneously well-defined conjugate properties expressed by a single value. The uncertainty principle implies that it is in general not possible to predict the value of a quantity with arbitrary certainty, even if all initial conditions are specified.

Charge, parity, and time reversal symmetry is a fundamental symmetry of physical laws under the simultaneous transformations of charge conjugation (C), parity transformation (P), and time reversal (T). CPT is the only combination of C, P, and T that is observed to be an exact symmetry of nature at the fundamental level.

In physical cosmology, the baryon asymmetry problem, also known as the matter asymmetry problem or the matter–antimatter asymmetry problem, is the observed imbalance in baryonic matter (the type of matter experienced in everyday life) and antibaryonic matter in the observable universe. Neither the standard model of particle physics, nor the theory of general relativity provides a known explanation for why this should be so, and it is a natural assumption that the universe is neutral with all conserved charges. The Big Bang should have produced equal amounts of matter and antimatter. Since this does not seem to have been the case, it is likely some physical laws must have acted differently or did not exist for matter and antimatter. Several competing hypotheses exist to explain the imbalance of matter and antimatter that resulted in baryogenesis. However, there is as of yet no consensus theory to explain the phenomenon, which has been described as “one of the great mysteries in physics”.

The no-hiding theorem states that if information is lost from a system via decoherence, then it moves to the subspace of the environment and it cannot remain in the correlation between the system and the environment. This is a fundamental consequence of the linearity and unitarity of quantum mechanics. Thus, information is never lost. This has implications in black hole information paradox and in fact any process that tends to lose information completely. The no-hiding theorem is robust to imperfection in the physical process that seemingly destroys the original information.